Abstract Background Mutations in amyloid precursor protein (APP). presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD). More than 280 pathogenic mutations have been reported in APP. PSEN1. https://fitnessgravesyardes.shop/product-category/photo-interrupter-kit/